Smarter HTP + Vitamin B6 made with hemp oil, bottle on a black reflective table.
Smarter 5-HTP
Smarter 5-HTP
Smarter 5-HTP
Smarter 5-HTP
Smarter 5-HTP + Vitamin B6 with hemp oil showing 4 benefits.
Smarter 5-HTP compared to other similar brands.
Reviews 800,000+ orders
5-HTP + vitamin B6 + hemp seed oil softgels

200 mg 5-HTP. 13.6 mg B6. One simple serving.

A two-softgel serving with 200 mg of 5-HTP from Griffonia simplicifolia seed, 13.6 mg of vitamin B6 as pyridoxine HCl, and 200 mg of hemp seed oil. Every amount is clearly disclosed - no proprietary blend, powder, or mixing.

200 mg 5-HTP from Griffonia Seed 13.6 mg Vitamin B6 Liquid Softgels with Hemp Seed Oil Third-Party Tested
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Benefits
  • Provides 5-HTP, the immediate biochemical precursor used by the body to synthesize serotonin.*
  • Vitamin B6 participates in normal neurotransmitter synthesis and nervous-system function.*
  • Provides clearly labeled amounts of both 5-HTP and vitamin B6 in one daily serving.
Ingredients

Each two-softgel serving provides:

5-HTP - 200 mg
from Griffonia simplicifolia seed

Vitamin B6 - 13.6 mg
as Pyridoxine HCl USP

Hemp Seed Oil - 200 mg

Other ingredients: softgel capsule (bovine gelatin, vegetable glycerin, annatto, purified water, berry flavor), beeswax, and sunflower lecithin.

60 softgels per bottle • 30 servings

Contains bovine gelatin. Not vegetarian or vegan.

Suggested Use

Take two softgels daily with a meal, or as directed by a healthcare professional.

Important: Do not combine 5-HTP with antidepressants or other medications or supplements that affect serotonin unless specifically approved by your healthcare professional. This includes many SSRIs, MAOIs, tricyclic antidepressants, and other serotonergic medications.

Consult a healthcare professional before use if you take prescription medication, use St. John's wort or SAM-e, take carbidopa, are pregnant or nursing, are preparing for surgery, or have a medical condition.

Do not use in children unless directed by a healthcare professional.

Smarter 250mg L-Theanine

Smarter 250mg L-Theanine

Pairs with your routine. Added to the same order.

$20.00

What's actually in the bottle.

200 mg 5-HTP

Sourced from Griffonia simplicifolia seed.

13.6 mg Vitamin B6

Pyridoxine HCl in the same daily serving.

Hemp Seed Oil

200 mg used as the oil carrier inside the liquid softgels.

Liquid Softgel Format

Two softgels per serving. No powder, scooping, or mixing.

Smarter 5-HTP bottle

5-HTP sits one step before serotonin.

Your body normally makes 5-HTP from the amino acid tryptophan. 5-HTP is then converted to serotonin through an enzyme-dependent pathway. Vitamin B6 participates broadly as a coenzyme in normal amino-acid and neurotransmitter metabolism.

See Supplement Facts

200 mg 5-HTP

Immediate precursor in the serotonin pathway

13.6 mg Vitamin B6

A nutrient involved in normal neurotransmitter biosynthesis

5-HTP softgel

200 mg Hemp Seed Oil

Oil carrier for the liquid-softgel format

What to look for in a 5-HTP supplement.

The source, serving amount, supporting ingredients, format, and testing are all worth checking.

Smarter 5-HTP What to Look For

5-HTP

200 mg per serving

Amount clearly disclosed

Source

Griffonia simplicifolia seed

Ingredient source identified

Vitamin B6

13.6 mg

Amount and form disclosed

Format

Liquid softgels

A format that fits your routine

Testing

Third-party tested

Independent quality testing

800,000+ Orders since 2016
2016 Independently owned
USA Made and tested
100% Third-party tested
Why Smarter Exists

Built on formulas, not fame.

Smarter Vitamins wasn't built with celebrity endorsements, influencer hype, or trendy marketing. We built it the harder way: make thoughtful formulas, show you what's inside, and let the product earn the repeat order.

Clear labels. No proprietary blends. Ingredients chosen for a reason - not because they look good in an ad. 800,000+ orders later, we're still doing it the same way.

- The Smarter Vitamins Team

The standards behind every bottle.

U.S. Manufacturing

Produced in established U.S. facilities

Established 2016

800,000+ orders and counting

Straightforward Formulas

Non-GMO ingredients. No proprietary blends.

cGMP Manufacturing

Produced under current Good Manufacturing Practices

Third-Party Tested

Independent laboratory testing for quality

FDA-Registered Facilities

Manufactured in FDA-registered facilities

Why Smarter 5-HTP

Know exactly what you're taking.

200 mg 5-HTP, 13.6 mg vitamin B6, and 200 mg hemp seed oil - clearly disclosed in every daily serving.

Griffonia simplicifolia

The 5-HTP is sourced from Griffonia simplicifolia seed, a botanical source commonly used for supplemental 5-HTP.

Clearly Labeled

Every two-softgel serving provides 200 mg of 5-HTP. No proprietary blend hiding the amount.

13.6 mg B6 Included

Vitamin B6 as pyridoxine HCl is included alongside the 5-HTP and clearly listed on the Supplement Facts panel.

No Powder. No Mixing.

5-HTP, vitamin B6, and hemp seed oil delivered in two convenient liquid softgels.

One Daily Serving

Two softgels taken together with a meal according to the Suggested Use.

Oil-Based Format

200 mg of hemp seed oil serves as the oil carrier inside the softgels. We do not make CBD, THC, or therapeutic claims about the hemp seed oil.

Independent Quality Testing

Third-party testing adds another layer of verification beyond what's printed on the label.

Check Your Medications

Because 5-HTP affects serotonin pathways, check with a healthcare professional before use if you take antidepressants or other serotonergic medications or supplements.

200 mg 5-HTP · 13.6 mg vitamin B6 · two softgels daily with a meal · 30 servings per bottle

Smarter 5-HTP $22.00
The research

Research & References

Selected independent resources on 5-HTP and vitamin B6. These references discuss the individual ingredients and their physiology - not Smarter 5-HTP or this specific finished formulation.

01 Maffei ME. 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology. A broad scientific review covering 5-HTP's natural sources, biochemical pathway, conversion to serotonin, published human and preclinical research, and safety considerations. The article is background on the ingredient and should not be interpreted as proof that this product treats any medical condition. International Journal of Molecular Sciences. 2020;22(1):181. 02 NIH Office of Dietary Supplements Vitamin B6 - Fact Sheet for Health Professionals. An authoritative overview of vitamin B6, including its roles in enzyme reactions, amino-acid metabolism, neurotransmitter biosynthesis, recommended intake, safety, and medication interactions. ods.od.nih.gov

These references are provided for educational purposes and discuss individual ingredients. They are not clinical studies of Smarter 5-HTP + Vitamin B6 or this specific formulation and should not be interpreted as evidence that this product diagnoses, treats, cures, or prevents disease.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Good to know

FAQs

5-HTP stands for 5-hydroxytryptophan.

Your body normally produces 5-HTP from the amino acid tryptophan. 5-HTP is then converted in a subsequent biochemical step into serotonin.

Smarter 5-HTP provides 200 mg per serving from Griffonia simplicifolia seed.

5-HTP is the immediate biochemical precursor to serotonin.

That does not mean that taking a 5-HTP supplement guarantees a particular mood, sleep, anxiety, appetite, or cognitive outcome. Individual biology, medications, health status, dose, and other factors all matter.

Vitamin B6 functions as a coenzyme in many reactions in the body, including reactions involved in amino-acid metabolism and neurotransmitter biosynthesis.

Each serving provides 13.6 mg of vitamin B6 as pyridoxine HCl.

We would not claim that simply adding more B6 automatically causes more 5-HTP to be converted to serotonin.

Take two softgels daily with a meal, according to the Suggested Use.

Because people can respond differently to 5-HTP, avoid driving or performing activities requiring full alertness until you know how it affects you.

Not without medical guidance.

5-HTP affects serotonin pathways and can interact with antidepressants and other serotonergic medications. People taking SSRIs, MAOIs, tricyclic antidepressants, or other medications affecting serotonin should not add 5-HTP without guidance from the healthcare professional managing their treatment.

Use particular caution with products that also affect serotonin, including St. John's wort and SAM-e.

5-HTP can also interact with medications such as linezolid and carbidopa. If you take prescription medications and are not sure whether they interact with serotonin, ask your physician or pharmacist before use.

Serotonin syndrome is a potentially serious reaction caused by excessive serotonergic activity.

Possible symptoms can include agitation, confusion, shivering, sweating, fever, rapid heartbeat, tremor, poor coordination, muscle rigidity, nausea, vomiting, or diarrhea.

Seek urgent medical attention if concerning symptoms develop after combining serotonergic products.

We don't guarantee either outcome.

5-HTP has been studied for sleep and mood-related outcomes, but studies differ considerably in population, dose, design, and quality. The product is not intended to treat depression, anxiety, insomnia, or any other medical condition.

The 200 mg of hemp seed oil is used as the oil carrier inside the liquid softgels.

It is not included as a CBD product, and we do not claim CBD- or THC-related effects from the hemp seed oil.

It is substantially higher than the U.S. Daily Value of 1.7 mg, so check your other supplements - especially B-complex products and multivitamins - before stacking additional B6.

Long-term excessive vitamin B6 supplementation can cause nerve problems, so more is not automatically better.

Speak with a healthcare professional before use if you:

  • take antidepressants or other serotonergic medications;
  • take carbidopa or linezolid;
  • use St. John's wort, SAM-e, or other serotonin-related supplements;
  • are pregnant, trying to become pregnant, or nursing;
  • are preparing for surgery;
  • have a medical condition; or
  • are considering use in a child.

The softgel contains bovine gelatin, so the product is not vegetarian or vegan.

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